![](/images/graphics-bg.png)
The Platelet microRNA Profile of Kawasaki Disease: Identification of Novel Diagnostic Biomarkers
المؤلفون المشاركون
Ding, Guohui
Zhang, Hong
Ning, Qianqian
Chen, Liqin
Song, Sirui
Xu, Kangping
Liu, Jia
Zhou, Yiwen
Zang, Chenyang
Li, Guang
Chen, Feng
Jia, Jia
Huang, Min
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Challenging diagnosis and unknown etiology of Kawasaki disease (KD) increase the coronary artery lesions incidence.
microRNAs (miRNAs) are the most promising biomarkers because of their stability in peripheral blood and noninvasive measurement procedure, whose potential utility have been proved in cancers.
To explore the utility of differentially expressed (DE) miRNAs as early diagnostic markers, 44 patients (25 incomplete KD and 19 complete KD) and 31 febrile controls were recruited for small RNA sequencing.
From all the 1922 expressed miRNA, 210 DE miRNAs were found between KD and febrile control groups.
Though platelet miRNA profiles of complete KD incomplete KD were much similar through cluster analysis, the DE miRNAs were not identical.
Eight DE miRNAs were validated by real-time quantitative PCR (qRT-PCR) in complete or incomplete KD groups using a normalizer, miR-126-3p, which was identified by geNorm and NormFinder tools.
The expression level of miRNAs continuous changed over time was observed and the function analysis showed the potential role of miRNAs as therapeutic biomarkers.
Additionally, the prediction model for KD showed a sensitivity of 78.8% and a specificity of 71.4%, respectively.
This study used small RNA sequencing to identify miRNA biomarkers KD diagnosis based on a large sample size.
Our findings shine a light on the understanding of molecular pathogenesis of KD and may improve the accuracy of KD diagnosis and prognosis in clinical.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ning, Qianqian& Chen, Liqin& Song, Sirui& Zhang, Hong& Xu, Kangping& Liu, Jia…[et al.]. 2020. The Platelet microRNA Profile of Kawasaki Disease: Identification of Novel Diagnostic Biomarkers. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1137938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ning, Qianqian…[et al.]. The Platelet microRNA Profile of Kawasaki Disease: Identification of Novel Diagnostic Biomarkers. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1137938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ning, Qianqian& Chen, Liqin& Song, Sirui& Zhang, Hong& Xu, Kangping& Liu, Jia…[et al.]. The Platelet microRNA Profile of Kawasaki Disease: Identification of Novel Diagnostic Biomarkers. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1137938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)