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The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats
المؤلفون المشاركون
Xu, Min
Tang, Huaqiao
Rong, Qian
Zhang, Yuanli
Li, Yinglun
Zhao, Ling
Ye, Gang
Shi, Fei
Lv, Cheng
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Formaldehyde (FA) is an occupational and indoor pollutant.
Long-term exposure to FA can irritate the respiratory mucosa, with potential carcinogenic effects on the airways.
The effects of acute FA poisoning on the activities of CYP450 isoforms CYP1A2, CYP2C11, CYP2E1, and CYP3A2 were assessed by determining changes in the pharmacokinetic parameters of the probe drugs phenacetin, tolbutamide, chlorzoxazone, and testosterone, respectively.
Rats were randomly divided into three groups: control, low FA dose (exposure to 110 ppm for 2 h for 3 days), and high FA dose (exposure to 220 ppm for 2 h for 3 days).
A mixture of the four probe drugs was injected into rats and blood samples were taken at a series of time points.
Plasma concentrations of the probe drugs were measured by HPLC.
The pharmacokinetic parameters t1/2, AUC(0-t), and Cmax of tolbutamide, chlorzoxazone, and testosterone increased significantly in the high dose versus control group (P<0.05), whereas the CL of chlorzoxazone and testosterone decreased significantly (P<0.05).
However, t1/2, AUC(0-t), and Cmax of phenacetin decreased significantly (P<0.05), whereas the CL of phenacetin increased significantly (P<0.05) compared to controls.
Thus, acute FA poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats.
And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Min& Tang, Huaqiao& Rong, Qian& Zhang, Yuanli& Li, Yinglun& Zhao, Ling…[et al.]. 2017. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138140
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Min…[et al.]. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138140
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Min& Tang, Huaqiao& Rong, Qian& Zhang, Yuanli& Li, Yinglun& Zhao, Ling…[et al.]. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138140
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138140
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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