The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats
Joint Authors
Xu, Min
Tang, Huaqiao
Rong, Qian
Zhang, Yuanli
Li, Yinglun
Zhao, Ling
Ye, Gang
Shi, Fei
Lv, Cheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Formaldehyde (FA) is an occupational and indoor pollutant.
Long-term exposure to FA can irritate the respiratory mucosa, with potential carcinogenic effects on the airways.
The effects of acute FA poisoning on the activities of CYP450 isoforms CYP1A2, CYP2C11, CYP2E1, and CYP3A2 were assessed by determining changes in the pharmacokinetic parameters of the probe drugs phenacetin, tolbutamide, chlorzoxazone, and testosterone, respectively.
Rats were randomly divided into three groups: control, low FA dose (exposure to 110 ppm for 2 h for 3 days), and high FA dose (exposure to 220 ppm for 2 h for 3 days).
A mixture of the four probe drugs was injected into rats and blood samples were taken at a series of time points.
Plasma concentrations of the probe drugs were measured by HPLC.
The pharmacokinetic parameters t1/2, AUC(0-t), and Cmax of tolbutamide, chlorzoxazone, and testosterone increased significantly in the high dose versus control group (P<0.05), whereas the CL of chlorzoxazone and testosterone decreased significantly (P<0.05).
However, t1/2, AUC(0-t), and Cmax of phenacetin decreased significantly (P<0.05), whereas the CL of phenacetin increased significantly (P<0.05) compared to controls.
Thus, acute FA poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats.
And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways.
American Psychological Association (APA)
Xu, Min& Tang, Huaqiao& Rong, Qian& Zhang, Yuanli& Li, Yinglun& Zhao, Ling…[et al.]. 2017. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138140
Modern Language Association (MLA)
Xu, Min…[et al.]. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138140
American Medical Association (AMA)
Xu, Min& Tang, Huaqiao& Rong, Qian& Zhang, Yuanli& Li, Yinglun& Zhao, Ling…[et al.]. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138140