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The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer
المؤلفون المشاركون
Jiao, Yan
Li, Yanqing
Wang, Ruobing
Ye, Siyang
Pan, Guoqiang
Qin, Shanshan
Hua, Fang
Liu, Yahui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Liver cancer is a devastating disease for humans with poor prognosis.
Although the survival rate of patients with liver cancer has improved in the past decades, the recurrence and metastasis of liver cancer are still obstacles for us.
Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in cancers.
However, there have been few studies on the correlation of INPP5K and liver cancer.
In this study, we explored the prognostic significance of INPP5K in liver cancer through bioinformatics analysis of data collected from The Cancer Genome Atlas (TCGA) database.
Chi-square and Fisher exact tests were used to evaluate the relationship between INPP5K expression and clinical characteristics.
Our results showed that low INPP5K expression was correlated with poor outcomes in liver cancer patients.
Univariate and multivariate Cox analyses demonstrated that low INPP5K mRNA expression played a significant role in shortening overall survival (OS) and relapse-free survival (RFS), which might serve as the useful biomarker and prognostic factor for liver cancer.
In conclusion, low INPP5K mRNA expression is an independent risk factor for poor prognosis in liver cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ruobing& Jiao, Yan& Li, Yanqing& Ye, Siyang& Pan, Guoqiang& Qin, Shanshan…[et al.]. 2020. The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ruobing…[et al.]. The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ruobing& Jiao, Yan& Li, Yanqing& Ye, Siyang& Pan, Guoqiang& Qin, Shanshan…[et al.]. The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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