Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population
المؤلفون المشاركون
Zhang, Xingang
Zheng, Liqiang
Li, Hong
Yu, Shasha
Wang, Rui
Sun, Zhaoqing
Zhou, Xinghu
Yin, Zhihua
Sun, Yingxian
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Introduction.
Ischemic stroke is a complex disorder resulting from the interplay of genetic and environmental factors.
Previous studies showed that kalirin gene variations were associated with cardiovascular disease.
However, the association between this gene and ischemic stroke was unknown.
We performed this study to confirm if kalirin gene variation was associated with ischemic stroke.
Methods.
We enrolled 385 ischemic stroke patients and 362 controls from China.
Three SNPs of kalirin gene were genotyped by means of ligase detection reaction-PCR method.
Data was processed with SPSS and SHEsis platform.
Results.
SNP rs7620580 (dominant model: OR = 1.590, p = 0.002 and adjusted OR = 1.662, p = 0.014; additive model: OR = 1.490, p = 0.002 and adjusted OR = 1.636, p = 0.005; recessive model: OR = 2.686, p = 0.039) and SNP rs1708303 (dominant model: OR = 1.523, p = 0.007 and adjusted OR = 1.604, p = 0.028; additive model: OR = 1.438, p = 0.01 and adjusted OR = 1.476, p = 0.039) were associated with ischemic stroke.
The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively.
Haplotype analysis revealed that A–T–G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke.
Conclusions.
Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Hong& Yu, Shasha& Wang, Rui& Sun, Zhaoqing& Zhou, Xinghu& Zheng, Liqiang…[et al.]. 2017. Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Hong…[et al.]. Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Hong& Yu, Shasha& Wang, Rui& Sun, Zhaoqing& Zhou, Xinghu& Zheng, Liqiang…[et al.]. Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر