Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population
Joint Authors
Zhang, Xingang
Zheng, Liqiang
Li, Hong
Yu, Shasha
Wang, Rui
Sun, Zhaoqing
Zhou, Xinghu
Yin, Zhihua
Sun, Yingxian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Ischemic stroke is a complex disorder resulting from the interplay of genetic and environmental factors.
Previous studies showed that kalirin gene variations were associated with cardiovascular disease.
However, the association between this gene and ischemic stroke was unknown.
We performed this study to confirm if kalirin gene variation was associated with ischemic stroke.
Methods.
We enrolled 385 ischemic stroke patients and 362 controls from China.
Three SNPs of kalirin gene were genotyped by means of ligase detection reaction-PCR method.
Data was processed with SPSS and SHEsis platform.
Results.
SNP rs7620580 (dominant model: OR = 1.590, p = 0.002 and adjusted OR = 1.662, p = 0.014; additive model: OR = 1.490, p = 0.002 and adjusted OR = 1.636, p = 0.005; recessive model: OR = 2.686, p = 0.039) and SNP rs1708303 (dominant model: OR = 1.523, p = 0.007 and adjusted OR = 1.604, p = 0.028; additive model: OR = 1.438, p = 0.01 and adjusted OR = 1.476, p = 0.039) were associated with ischemic stroke.
The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively.
Haplotype analysis revealed that A–T–G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke.
Conclusions.
Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.
American Psychological Association (APA)
Li, Hong& Yu, Shasha& Wang, Rui& Sun, Zhaoqing& Zhou, Xinghu& Zheng, Liqiang…[et al.]. 2017. Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138162
Modern Language Association (MLA)
Li, Hong…[et al.]. Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138162
American Medical Association (AMA)
Li, Hong& Yu, Shasha& Wang, Rui& Sun, Zhaoqing& Zhou, Xinghu& Zheng, Liqiang…[et al.]. Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138162