MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels

الملخص EN

There is growing evidence that microRNA-148b (miR-148b) can inhibit the growth of malignant cells while sirtuin 7 (SIRT7) may perform its carcinogenic effect by deacetylating H3K18.

This study investigated the mechanism of miR-148b/SIRT7 on how it affects the malignant biological behavior of melanoma.

It was established that the expression of miR-148b was downregulated in melanoma while that of SIRT7 was upregulated but negatively regulated by miR-148b through binding to the 3′UTR of SIRT7.

Ectopic expression of miR-148b reduced the proliferation, migration, and invasion of melanoma cells, but SIRT7 reversed these functions of miR-148b.

Moreover, tumor growth and metastasis experiments showed that miR-148b could significantly suppress proliferation and metastasis of melanoma in vivo.

Overall, miR-148b inhibits the malignant biological behavior of melanoma by reducing the expression level of SIRT7.

The development of miR-148b as a novel potential therapeutic approach for melanoma may be possible in the future.