MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels
Joint Authors
Meng, Qinqin
Guo, Meiliang
Fan, Xiaojing
Yuan, Dingfen
Yang, Xinrong
Yan, Kexiang
Deng, Hui
Sun, Rui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
There is growing evidence that microRNA-148b (miR-148b) can inhibit the growth of malignant cells while sirtuin 7 (SIRT7) may perform its carcinogenic effect by deacetylating H3K18.
This study investigated the mechanism of miR-148b/SIRT7 on how it affects the malignant biological behavior of melanoma.
It was established that the expression of miR-148b was downregulated in melanoma while that of SIRT7 was upregulated but negatively regulated by miR-148b through binding to the 3′UTR of SIRT7.
Ectopic expression of miR-148b reduced the proliferation, migration, and invasion of melanoma cells, but SIRT7 reversed these functions of miR-148b.
Moreover, tumor growth and metastasis experiments showed that miR-148b could significantly suppress proliferation and metastasis of melanoma in vivo.
Overall, miR-148b inhibits the malignant biological behavior of melanoma by reducing the expression level of SIRT7.
The development of miR-148b as a novel potential therapeutic approach for melanoma may be possible in the future.
American Psychological Association (APA)
Sun, Rui& Guo, Meiliang& Fan, Xiaojing& Meng, Qinqin& Yuan, Dingfen& Yang, Xinrong…[et al.]. 2020. MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138177
Modern Language Association (MLA)
Sun, Rui…[et al.]. MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1138177
American Medical Association (AMA)
Sun, Rui& Guo, Meiliang& Fan, Xiaojing& Meng, Qinqin& Yuan, Dingfen& Yang, Xinrong…[et al.]. MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138177