lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761
المؤلفون المشاركون
Li, Ying
Fang, Bin
Xu, Liangliang
Zheng, Jiaqian
Huang, Yanni
Lai, Jieqing
Chen, Chen
Yi, Chunzhi
Pang, Fengxiang
Lan, Yun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mounting evidences have indicated that terminal differentiation-induced lncRNA (TINCR) contributes to various cellular processes, such as proliferation, apoptosis, autophagy, migration, invasion, and metastasis.
However, the function of TINCR in regulating migration of MSCs is largely unknown.
In this study, the effects of TINCR on the migration of rat MSCs from the bone marrow were studied by Transwell assays and wound healing assays.
Our results suggested that TINCR positively regulated migration of rMSCs.
miR-761 mimics suppressed rMSC migration, whereas miR-761 inhibitor promoted migration.
Target prediction analysis tools and dual-luciferase reporter gene assay identified Wnt2 as a direct target of miR-761.
miR-761 could inhibit the expression of Wnt2.
Further, the investigation about the function of TINCR in miR-761-induced migration of rMSCs was completed.
These results demonstrated that TINCR took part in the regulation of miR-761-induced migration in rMSCs through the regulation of Wnt2 and its Wnt2 signaling pathway.
Taken together, our results demonstrate that lncRNA-TINCR functions as a competitive endogenous RNA (ceRNA) to regulate the migration of rMSCs by sponging miR-761 which modulates the role of Wnt2.
These findings provide evidence that lncRNA-TINCR has a chance to serve as a potential target for enhancing MSC homing through the miR-761/Wnt2 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Jiaqian& Huang, Yanni& Li, Ying& Lai, Jieqing& Chen, Chen& Yi, Chunzhi…[et al.]. 2020. lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Jiaqian…[et al.]. lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Jiaqian& Huang, Yanni& Li, Ying& Lai, Jieqing& Chen, Chen& Yi, Chunzhi…[et al.]. lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر