lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761
Joint Authors
Li, Ying
Fang, Bin
Xu, Liangliang
Zheng, Jiaqian
Huang, Yanni
Lai, Jieqing
Chen, Chen
Yi, Chunzhi
Pang, Fengxiang
Lan, Yun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mounting evidences have indicated that terminal differentiation-induced lncRNA (TINCR) contributes to various cellular processes, such as proliferation, apoptosis, autophagy, migration, invasion, and metastasis.
However, the function of TINCR in regulating migration of MSCs is largely unknown.
In this study, the effects of TINCR on the migration of rat MSCs from the bone marrow were studied by Transwell assays and wound healing assays.
Our results suggested that TINCR positively regulated migration of rMSCs.
miR-761 mimics suppressed rMSC migration, whereas miR-761 inhibitor promoted migration.
Target prediction analysis tools and dual-luciferase reporter gene assay identified Wnt2 as a direct target of miR-761.
miR-761 could inhibit the expression of Wnt2.
Further, the investigation about the function of TINCR in miR-761-induced migration of rMSCs was completed.
These results demonstrated that TINCR took part in the regulation of miR-761-induced migration in rMSCs through the regulation of Wnt2 and its Wnt2 signaling pathway.
Taken together, our results demonstrate that lncRNA-TINCR functions as a competitive endogenous RNA (ceRNA) to regulate the migration of rMSCs by sponging miR-761 which modulates the role of Wnt2.
These findings provide evidence that lncRNA-TINCR has a chance to serve as a potential target for enhancing MSC homing through the miR-761/Wnt2 signaling pathway.
American Psychological Association (APA)
Zheng, Jiaqian& Huang, Yanni& Li, Ying& Lai, Jieqing& Chen, Chen& Yi, Chunzhi…[et al.]. 2020. lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138185
Modern Language Association (MLA)
Zheng, Jiaqian…[et al.]. lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138185
American Medical Association (AMA)
Zheng, Jiaqian& Huang, Yanni& Li, Ying& Lai, Jieqing& Chen, Chen& Yi, Chunzhi…[et al.]. lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138185