![](/images/graphics-bg.png)
Quantitative Serum Proteomic Analysis of Essential Hypertension Using iTRAQ Technique
المؤلفون المشاركون
Jiang, Haiqiang
Xu, Jing-Wen
Li, Yun-Lun
Zhang, Shi-Jun
Yang, Wen-Qing
Nie, Wen-Ting
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Essential hypertension (EH) is a risk factor for some severe diseases.
This study aimed to screen out serum special proteins and seek interaction between them, which would provide new therapeutic targets and elucidate the comprehensive pathophysiological mechanism for EH.
Patients with EH (Group A, n=47) and healthy controls (HC) (Group B, n=47) were recruited in this study.
Serums from the two groups were analyzed with isobaric tags for relative and absolute quantitation coupled two-dimensional liquid chromatography followed by electrospray ionization-tandem mass spectrometry technique, while the candidate special proteins were verified with ELISA and western blot.
A total of 404 proteins were identified, of which 30 proteins were upregulated (>1.2-fold, p<0.05) and 81 proteins were downregulated (<0.833-fold, p<0.05) compared with HC group.
With GO, KEGG analysis, and literature retrieval, 4 proteins, cathepsin G, transforming growth factor beta-1, hyaluronidase-1, and kininogen-1, were found jointly involved in the renin-angiotensin-aldosterone system and kallikrein-kinin system.
The profiles of these 4 candidate proteins were confirmed with ELISA and western blot.
The concentration variation of these 4 proteins could better predict the occurrence and illustrate the pathophysiological mechanism of EH.
And their discovery may help pave the way for exploring new therapies of EH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Jing-Wen& Li, Yun-Lun& Zhang, Shi-Jun& Yang, Wen-Qing& Nie, Wen-Ting& Jiang, Haiqiang. 2017. Quantitative Serum Proteomic Analysis of Essential Hypertension Using iTRAQ Technique. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138211
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Jing-Wen…[et al.]. Quantitative Serum Proteomic Analysis of Essential Hypertension Using iTRAQ Technique. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138211
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Jing-Wen& Li, Yun-Lun& Zhang, Shi-Jun& Yang, Wen-Qing& Nie, Wen-Ting& Jiang, Haiqiang. Quantitative Serum Proteomic Analysis of Essential Hypertension Using iTRAQ Technique. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138211
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138211
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)