Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea
المؤلفون المشاركون
Li, Yanmei
Hao, Dan
Wang, Yujia
Jiang, Xian
Wang, Lian
Lu, Ruifeng
Wang, Xiaoyun
Wen, Xiang
Zeng, Minghui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life.
However, the molecular characterization of each rosacea subtype is still unclear.
Furthermore, little is known about the role of long noncoding RNAs (lncRNAs) in the pathogenesis or regulatory processes of this disorder.
In the current study, we established lncRNA-mRNA coexpression networks for three rosacea subtypes (erythematotelangiectatic, papulopustular, and phymatous) and performed their functional enrichment analyses using Gene Onotology, KEGG, GSEA, and WGCNA.
Compared to the control group, 13 differentially expressed lncRNAs and 525 differentially expressed mRNAs were identified in the three rosacea subtypes.
The differentially expressed genes identified were enriched in four signaling pathways and the GO terms found were associated with leukocyte migration.
In addition, we found nine differentially expressed lncRNAs in all three rosacea subtype-related networks, including NEAT1 and HOTAIR, which may play important roles in the pathology of rosacea.
Our study provided novel insights into lncRNA-mRNA coexpression networks to discover the molecular mechanisms involved in rosacea development that can be used as future targets of rosacea diagnosis, prevention, and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lian& Lu, Ruifeng& Wang, Yujia& Wang, Xiaoyun& Hao, Dan& Wen, Xiang…[et al.]. 2020. Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138241
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lian…[et al.]. Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1138241
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lian& Lu, Ruifeng& Wang, Yujia& Wang, Xiaoyun& Hao, Dan& Wen, Xiang…[et al.]. Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138241
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138241
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر