Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea
Joint Authors
Li, Yanmei
Hao, Dan
Wang, Yujia
Jiang, Xian
Wang, Lian
Lu, Ruifeng
Wang, Xiaoyun
Wen, Xiang
Zeng, Minghui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life.
However, the molecular characterization of each rosacea subtype is still unclear.
Furthermore, little is known about the role of long noncoding RNAs (lncRNAs) in the pathogenesis or regulatory processes of this disorder.
In the current study, we established lncRNA-mRNA coexpression networks for three rosacea subtypes (erythematotelangiectatic, papulopustular, and phymatous) and performed their functional enrichment analyses using Gene Onotology, KEGG, GSEA, and WGCNA.
Compared to the control group, 13 differentially expressed lncRNAs and 525 differentially expressed mRNAs were identified in the three rosacea subtypes.
The differentially expressed genes identified were enriched in four signaling pathways and the GO terms found were associated with leukocyte migration.
In addition, we found nine differentially expressed lncRNAs in all three rosacea subtype-related networks, including NEAT1 and HOTAIR, which may play important roles in the pathology of rosacea.
Our study provided novel insights into lncRNA-mRNA coexpression networks to discover the molecular mechanisms involved in rosacea development that can be used as future targets of rosacea diagnosis, prevention, and treatment.
American Psychological Association (APA)
Wang, Lian& Lu, Ruifeng& Wang, Yujia& Wang, Xiaoyun& Hao, Dan& Wen, Xiang…[et al.]. 2020. Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138241
Modern Language Association (MLA)
Wang, Lian…[et al.]. Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1138241
American Medical Association (AMA)
Wang, Lian& Lu, Ruifeng& Wang, Yujia& Wang, Xiaoyun& Hao, Dan& Wen, Xiang…[et al.]. Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138241