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Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study)
المؤلفون المشاركون
Pyun, Chang-Won
Seo, Tae-Su
Kim, Dae-Jung
Kim, Tae-Woo
Bae, Jung-Shik
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Hepatic protective effects of Ligularia fischeri (LF) and Aronia melanocarpa (AM) against alcohol were investigated in vitro and in vivo test.
LF, AM, and those composed mixing material (LF+AM) were treated in HepG2 cell.
Alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly increased in each singleness extract and mixed composite.
The protective effect on alcoholic liver damage was investigated by animal models.
Serum alcohol level and acetaldehyde level were significantly decreased by LF+AM treatment in acute experimental model.
In the chronic mouse model study, we had found that the increased plasma liver damage index (alkaline phosphatase) by alcohol treatment was declined by oral administration of LF+AM extraction composite.
As well as, it was identified that the protection effect was induced by increasing catalase activity and suppressing COX-2, TNF-α, MCP-1, and IL-6 mRNA expressions.
CYP2E1 mRNA expression was also increased.
These results suggest that oral ingestion of LF and AM mixed composite is able to protect liver against alcohol-induced injury by increasing alcohol metabolism activity and antioxidant system along with decreasing inflammatory responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pyun, Chang-Won& Seo, Tae-Su& Kim, Dae-Jung& Kim, Tae-Woo& Bae, Jung-Shik. 2020. Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study). BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pyun, Chang-Won…[et al.]. Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study). BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pyun, Chang-Won& Seo, Tae-Su& Kim, Dae-Jung& Kim, Tae-Woo& Bae, Jung-Shik. Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study). BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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