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Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study)
Joint Authors
Pyun, Chang-Won
Seo, Tae-Su
Kim, Dae-Jung
Kim, Tae-Woo
Bae, Jung-Shik
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatic protective effects of Ligularia fischeri (LF) and Aronia melanocarpa (AM) against alcohol were investigated in vitro and in vivo test.
LF, AM, and those composed mixing material (LF+AM) were treated in HepG2 cell.
Alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly increased in each singleness extract and mixed composite.
The protective effect on alcoholic liver damage was investigated by animal models.
Serum alcohol level and acetaldehyde level were significantly decreased by LF+AM treatment in acute experimental model.
In the chronic mouse model study, we had found that the increased plasma liver damage index (alkaline phosphatase) by alcohol treatment was declined by oral administration of LF+AM extraction composite.
As well as, it was identified that the protection effect was induced by increasing catalase activity and suppressing COX-2, TNF-α, MCP-1, and IL-6 mRNA expressions.
CYP2E1 mRNA expression was also increased.
These results suggest that oral ingestion of LF and AM mixed composite is able to protect liver against alcohol-induced injury by increasing alcohol metabolism activity and antioxidant system along with decreasing inflammatory responses.
American Psychological Association (APA)
Pyun, Chang-Won& Seo, Tae-Su& Kim, Dae-Jung& Kim, Tae-Woo& Bae, Jung-Shik. 2020. Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study). BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138256
Modern Language Association (MLA)
Pyun, Chang-Won…[et al.]. Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study). BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138256
American Medical Association (AMA)
Pyun, Chang-Won& Seo, Tae-Su& Kim, Dae-Jung& Kim, Tae-Woo& Bae, Jung-Shik. Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study). BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138256