The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania
المؤلفون المشاركون
Buza, Joram
Munisi, David Z.
Mpolya, Emmanuel A.
Kinung’hi, Safari M.
Angelo, Teckla
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Administering more than one treatment may increase Praziquantel cure and egg reduction rates, thereby hastening achievement of schistosomiasis transmission control.
A total of 431 S.
mansoni-infected schoolchildren were randomized to receive either a single or repeated 40 mg/kg Praziquantel dose.
Heights, weights, and haemoglobin levels were determined using a stadiometer, weighing scale, and HemoCue, respectively.
At 8 weeks, cure rate was higher on repeated dose (93.10%) compared to single dose (68.68%) (p<0.001).
The egg reduction rate was higher on repeated dose (97.54%) compared to single dose (87.27%) (p=0.0062).
Geometric mean egg intensity was lower among those on repeated dose (1.30 epg) compared to single dose (3.18 epg) (p=0.036) but not at 5 (p>0.05) and 8 (p>0.05) months with no difference in reinfection rate.
No difference in the prevalence of stunting was observed between the two treatment regimens (p>0.05) at 8 months, but there was an increase in the prevalence of wasting among those on repeated dose (p<0.001).
There was an increase in the mean haemoglobin levels at 8 months with no difference between the two arms (p>0.05).
To achieve reduction of transmission intensity and disease control in highly endemic areas, repeated treatments alone may not be sufficient.
This trial was registered with PACTR201601001416338.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Munisi, David Z.& Buza, Joram& Mpolya, Emmanuel A.& Angelo, Teckla& Kinung’hi, Safari M.. 2017. The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138340
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Munisi, David Z.…[et al.]. The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138340
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Munisi, David Z.& Buza, Joram& Mpolya, Emmanuel A.& Angelo, Teckla& Kinung’hi, Safari M.. The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138340
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138340
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر