MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice

المؤلفون المشاركون

Wu, Xiaodong
Wu, Jinting
Hu, Wenjie
Wang, Qinghua
Liu, Hairong
Chu, Zhaohu
Lv, Kun
Xu, Yang

المصدر

Behavioural Neurology

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-02-03

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص EN

Background.

The aim of this study was to explore the role of hesperadin in intracerebral hemorrhage (ICH) mice, with the involvement of the mammalian ste20-like kinase 4 (MST4)/AKT signaling pathway.

Methods.

All mice were divided into four groups: sham group, sham+hesperidin group, ICH group, and ICH+hesperadin group.

The effects of hesperadin were assessed on the basis of brain edema and neurobehavioral function.

Furthermore, we observed MST4, AKT, phosphorylation of AKT (pAKT), and microtubule-associated protein light chain 3 (LC3) by western blotting.

Protein localization of MST4 and LC3 was determined by immunofluorescence.

Results.

The expression of MST4 was upregulated at 12 h and 24 h after ICH.

Brain edema was significantly decreased and neurological function was improved in the hesperadin treatment group compared to the ICH group (P<0.05).

Hesperadin decreases the expressions of MST and increases pAKT after ICH.

Autophagy significantly increased in the ICH group, while hesperadin reduced this increase.

Conclusion.

Hesperadin provides neuroprotection against ICH by inhibiting the MST4/AKT signaling pathway.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Xiaodong& Wu, Jinting& Hu, Wenjie& Wang, Qinghua& Liu, Hairong& Chu, Zhaohu…[et al.]. 2020. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice. Behavioural Neurology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138367

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Xiaodong…[et al.]. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice. Behavioural Neurology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138367

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Xiaodong& Wu, Jinting& Hu, Wenjie& Wang, Qinghua& Liu, Hairong& Chu, Zhaohu…[et al.]. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice. Behavioural Neurology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138367

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1138367