MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice
Joint Authors
Wu, Xiaodong
Wu, Jinting
Hu, Wenjie
Wang, Qinghua
Liu, Hairong
Chu, Zhaohu
Lv, Kun
Xu, Yang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The aim of this study was to explore the role of hesperadin in intracerebral hemorrhage (ICH) mice, with the involvement of the mammalian ste20-like kinase 4 (MST4)/AKT signaling pathway.
Methods.
All mice were divided into four groups: sham group, sham+hesperidin group, ICH group, and ICH+hesperadin group.
The effects of hesperadin were assessed on the basis of brain edema and neurobehavioral function.
Furthermore, we observed MST4, AKT, phosphorylation of AKT (pAKT), and microtubule-associated protein light chain 3 (LC3) by western blotting.
Protein localization of MST4 and LC3 was determined by immunofluorescence.
Results.
The expression of MST4 was upregulated at 12 h and 24 h after ICH.
Brain edema was significantly decreased and neurological function was improved in the hesperadin treatment group compared to the ICH group (P<0.05).
Hesperadin decreases the expressions of MST and increases pAKT after ICH.
Autophagy significantly increased in the ICH group, while hesperadin reduced this increase.
Conclusion.
Hesperadin provides neuroprotection against ICH by inhibiting the MST4/AKT signaling pathway.
American Psychological Association (APA)
Wu, Xiaodong& Wu, Jinting& Hu, Wenjie& Wang, Qinghua& Liu, Hairong& Chu, Zhaohu…[et al.]. 2020. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice. Behavioural Neurology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138367
Modern Language Association (MLA)
Wu, Xiaodong…[et al.]. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice. Behavioural Neurology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138367
American Medical Association (AMA)
Wu, Xiaodong& Wu, Jinting& Hu, Wenjie& Wang, Qinghua& Liu, Hairong& Chu, Zhaohu…[et al.]. MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4AKT Pathway in Intracerebral Hemorrhage Mice. Behavioural Neurology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138367