Activity of Phosvitin in Hydroxyapatite Acid-Damage Immersion and Antimicrobial Assays
المؤلفون المشاركون
Shipman, Richard D.
Doering, Sean D.
Hemsath, Jack R.
Lee, Eun Joo
Grant, Jennifer E.
المصدر
Biochemistry Research International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Phosvitin, the most highly phosphorylated metal-binding protein found in nature, binds more than 100 calcium ions, and has been identified as an agent that could be used to generate biomineralization scaffolds.
Because of published reports describing phosvitin’s affinity for calcium and potential antibiotic activity, this study was undertaken in order to evaluate phosvitin for both antibiotic activity against common microorganisms and the ability to protect hydroxyapatite surfaces from acid damage.
To more clearly define its antibiotic action, the effects of phosvitin on Micrococcus luteus, P.
mirabilis, B.
cereus, E.
coli, and S.
epidermidis were evaluated.
In both Kirby–Bauer tests and liquid culture growth inhibition assays, phosvitin inhibited M.
luteus, a microorganism that thrives in the human mouth, but not the other bacteria tested.
The MIC of phosvitin was determined to be 31.3 μg/mL when delivered in 1 mM CaCl2 but was 0.5 mg/mL in the absence of added calcium.
Expanding on the potential impacts of phosvitin on the mouth, its action was evaluated in a model of tooth decay represented by acid-damaged hydroxyapatite discs.
SEM, AFM, and FAAS analyses revealed that pretreatment of discs with phosvitin modulated the damage-induced morphology and topography changes associated with acid-damaged discs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shipman, Richard D.& Doering, Sean D.& Hemsath, Jack R.& Lee, Eun Joo& Grant, Jennifer E.. 2020. Activity of Phosvitin in Hydroxyapatite Acid-Damage Immersion and Antimicrobial Assays. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shipman, Richard D.…[et al.]. Activity of Phosvitin in Hydroxyapatite Acid-Damage Immersion and Antimicrobial Assays. Biochemistry Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shipman, Richard D.& Doering, Sean D.& Hemsath, Jack R.& Lee, Eun Joo& Grant, Jennifer E.. Activity of Phosvitin in Hydroxyapatite Acid-Damage Immersion and Antimicrobial Assays. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر