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RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration
المؤلفون المشاركون
Grosjean, Fabrizio
Esposito, Pasquale
Maccarrone, Rosario
Libetta, Carmelo
Dal Canton, Antonio
Rampino, Teresa
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR).
In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD).
We also assessed how circulating RBP4 could be influenced by kidney transplant or different dialytic techniques.
Methods.
RBP4 serum levels were evaluated in HD (n=16) and matched healthy controls (C; n=16).
RBP4 and glucose transporter type 4 (GLUT4) mRNA expressions were also determined in adipose tissue.
Circulating RBP4 was evaluated after kidney transplant (n=7) and in hemodialysis patients (n=10) enrolled in a cross-over study treated with standard bicarbonate dialysis (BD) or hemodiafiltration (HDF).
Results.
HOMA index (P<0.05) and serum RBP4 (P<0.005) were higher in HD compared to C.
RBP4 levels positively correlated with fasting serum glucose (P<0.05).
RBP4 mRNA was lower in HD compared to C (P<0.05) and positively correlated with kidney function (P<0.05) and GLUT4 mRNA (P<0.001).
Transplant or HDF reduced circulating RBP4 (P<0.01 and P<0.05, resp.).
Our results demonstrate that IR is associated with high circulating RBP4 and that suppressed RBP4 adipose tissue expression is accompanied by reduced GLUT4 expression in HD.
Renal transplantation or HDF are effective in lowering serum RBP4 levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grosjean, Fabrizio& Esposito, Pasquale& Maccarrone, Rosario& Libetta, Carmelo& Dal Canton, Antonio& Rampino, Teresa. 2017. RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138490
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grosjean, Fabrizio…[et al.]. RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138490
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grosjean, Fabrizio& Esposito, Pasquale& Maccarrone, Rosario& Libetta, Carmelo& Dal Canton, Antonio& Rampino, Teresa. RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138490
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138490
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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