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RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration
Joint Authors
Grosjean, Fabrizio
Esposito, Pasquale
Maccarrone, Rosario
Libetta, Carmelo
Dal Canton, Antonio
Rampino, Teresa
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR).
In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD).
We also assessed how circulating RBP4 could be influenced by kidney transplant or different dialytic techniques.
Methods.
RBP4 serum levels were evaluated in HD (n=16) and matched healthy controls (C; n=16).
RBP4 and glucose transporter type 4 (GLUT4) mRNA expressions were also determined in adipose tissue.
Circulating RBP4 was evaluated after kidney transplant (n=7) and in hemodialysis patients (n=10) enrolled in a cross-over study treated with standard bicarbonate dialysis (BD) or hemodiafiltration (HDF).
Results.
HOMA index (P<0.05) and serum RBP4 (P<0.005) were higher in HD compared to C.
RBP4 levels positively correlated with fasting serum glucose (P<0.05).
RBP4 mRNA was lower in HD compared to C (P<0.05) and positively correlated with kidney function (P<0.05) and GLUT4 mRNA (P<0.001).
Transplant or HDF reduced circulating RBP4 (P<0.01 and P<0.05, resp.).
Our results demonstrate that IR is associated with high circulating RBP4 and that suppressed RBP4 adipose tissue expression is accompanied by reduced GLUT4 expression in HD.
Renal transplantation or HDF are effective in lowering serum RBP4 levels.
American Psychological Association (APA)
Grosjean, Fabrizio& Esposito, Pasquale& Maccarrone, Rosario& Libetta, Carmelo& Dal Canton, Antonio& Rampino, Teresa. 2017. RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138490
Modern Language Association (MLA)
Grosjean, Fabrizio…[et al.]. RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138490
American Medical Association (AMA)
Grosjean, Fabrizio& Esposito, Pasquale& Maccarrone, Rosario& Libetta, Carmelo& Dal Canton, Antonio& Rampino, Teresa. RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138490