Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy
المؤلفون المشاركون
Kim, Yang Gyun
Lee, Sang Ho
Jeong, Kyung-Hwan
Lee, Tae Won
Ihm, Chun Gyoo
Moon, Ju-Young
Kim, Da Rae
Lee, Shin Yeong
Kim, Jin Sug
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Previous studies have shown the antiapoptotic and anti-inflammatory potential of DPP-IV inhibitor in experimental models of renal injury.
We tested whether DPP-IV inhibitor (gemigliptin) ameliorates renal injury by suppressing apoptosis, inflammation, and oxidative stress in mice with adriamycin nephropathy.
Methods.
Mice were treated with normal saline (control), gemigliptin (GM), adriamycin (ADR), or adriamycin combined with gemigliptin (ADR+GM).
Apoptosis, inflammation, and oxidative stress were analyzed via western blotting, real-time PCR, light microscopy, and immunofluorescence.
Results.
In the ADR+GM group, urine albumin creatinine ratio decreased significantly compared with that in the ADR group on day 15.
Glomerulosclerosis index and tubulointerstitial injury index in mice with adriamycin-induced nephropathy decreased after gemigliptin treatment.
ADR group showed higher levels of apoptosis, inflammation, and oxidative stress-related molecules compared with the control group.
The upregulation of these molecules was significantly reduced by gemigliptin.
In the ADR group, the staining intensities of WT-1 and nephrin reduced, but these changes were ameliorated in the ADR+GM group.
Conclusion.
We demonstrated that gemigliptin ameliorates nephropathy by suppressing apoptosis, inflammation, and oxidative stress in mice administered adriamycin.
Our data demonstrate that gemigliptin has renoprotective effects on adriamycin-induced nephropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Da Rae& Lee, Shin Yeong& Kim, Jin Sug& Kim, Yang Gyun& Moon, Ju-Young& Lee, Sang Ho…[et al.]. 2017. Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Da Rae…[et al.]. Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Da Rae& Lee, Shin Yeong& Kim, Jin Sug& Kim, Yang Gyun& Moon, Ju-Young& Lee, Sang Ho…[et al.]. Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر