![](/images/graphics-bg.png)
Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy
Joint Authors
Kim, Yang Gyun
Lee, Sang Ho
Jeong, Kyung-Hwan
Lee, Tae Won
Ihm, Chun Gyoo
Moon, Ju-Young
Kim, Da Rae
Lee, Shin Yeong
Kim, Jin Sug
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Previous studies have shown the antiapoptotic and anti-inflammatory potential of DPP-IV inhibitor in experimental models of renal injury.
We tested whether DPP-IV inhibitor (gemigliptin) ameliorates renal injury by suppressing apoptosis, inflammation, and oxidative stress in mice with adriamycin nephropathy.
Methods.
Mice were treated with normal saline (control), gemigliptin (GM), adriamycin (ADR), or adriamycin combined with gemigliptin (ADR+GM).
Apoptosis, inflammation, and oxidative stress were analyzed via western blotting, real-time PCR, light microscopy, and immunofluorescence.
Results.
In the ADR+GM group, urine albumin creatinine ratio decreased significantly compared with that in the ADR group on day 15.
Glomerulosclerosis index and tubulointerstitial injury index in mice with adriamycin-induced nephropathy decreased after gemigliptin treatment.
ADR group showed higher levels of apoptosis, inflammation, and oxidative stress-related molecules compared with the control group.
The upregulation of these molecules was significantly reduced by gemigliptin.
In the ADR group, the staining intensities of WT-1 and nephrin reduced, but these changes were ameliorated in the ADR+GM group.
Conclusion.
We demonstrated that gemigliptin ameliorates nephropathy by suppressing apoptosis, inflammation, and oxidative stress in mice administered adriamycin.
Our data demonstrate that gemigliptin has renoprotective effects on adriamycin-induced nephropathy.
American Psychological Association (APA)
Kim, Da Rae& Lee, Shin Yeong& Kim, Jin Sug& Kim, Yang Gyun& Moon, Ju-Young& Lee, Sang Ho…[et al.]. 2017. Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138491
Modern Language Association (MLA)
Kim, Da Rae…[et al.]. Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138491
American Medical Association (AMA)
Kim, Da Rae& Lee, Shin Yeong& Kim, Jin Sug& Kim, Yang Gyun& Moon, Ju-Young& Lee, Sang Ho…[et al.]. Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138491