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Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery
المؤلفون المشاركون
Rudiger, Alain
Grest, Angelina
Kurmann, Judith
Müller, Markus
Jeger, Victor
Krüger, Bernard
Bettex, Dominique
Spahn, Donat R.
المصدر
Critical Care Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
The aim of this retrospective study was to assess the haemodynamic adverse effects of clonidine and dexmedetomidine in critically ill patients after cardiac surgery.
Methods.
2769 patients were screened during the 30-month study period.
Heart rate (HR), mean arterial pressure (MAP), and norepinephrine requirements were assessed 3-hourly during the first 12 hours of the continuous drug infusion.
Results are given as median (interquartile range) or numbers (percentages).
Results.
Patients receiving clonidine (n = 193) were younger (66 (57–73) vs 70 (63–77) years, p=0.003) and had a lower SAPS II (35 (27–48) vs 41 (31–54), p=0.008) compared with patients receiving dexmedetomidine (n = 141).
At the start of the drug infusion, HR (90 (75–100) vs 90 (80–105) bpm, p=0.028), MAP (70 (65–80) vs 70 (65–75) mmHg, p=0.093), and norepinephrine (0.05 (0.00–0.11) vs 0.12 (0.03–0.19) mcg/kg/min, p<0.001) were recorded in patients with clonidine and dexmedetomidine.
Bradycardia (HR < 60 bpm) developed in 7.8% with clonidine and 5.7% with dexmedetomidine (p=0.51).
Between baseline and 12 hours, norepinephrine remained stable in the clonidine group (0.00 (−0.04–0.02) mcg/kg/min) and decreased in the dexmedetomidine group (−0.03 (−0.10–0.02) mcg/kg/min, p=0.007).
Conclusions.
Dexmedetomidine and the low-cost drug clonidine can both be used safely in selected patients after cardiac surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grest, Angelina& Kurmann, Judith& Müller, Markus& Jeger, Victor& Krüger, Bernard& Spahn, Donat R.…[et al.]. 2020. Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery. Critical Care Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grest, Angelina…[et al.]. Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery. Critical Care Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grest, Angelina& Kurmann, Judith& Müller, Markus& Jeger, Victor& Krüger, Bernard& Spahn, Donat R.…[et al.]. Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery. Critical Care Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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