Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery
Joint Authors
Rudiger, Alain
Grest, Angelina
Kurmann, Judith
Müller, Markus
Jeger, Victor
Krüger, Bernard
Bettex, Dominique
Spahn, Donat R.
Source
Critical Care Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The aim of this retrospective study was to assess the haemodynamic adverse effects of clonidine and dexmedetomidine in critically ill patients after cardiac surgery.
Methods.
2769 patients were screened during the 30-month study period.
Heart rate (HR), mean arterial pressure (MAP), and norepinephrine requirements were assessed 3-hourly during the first 12 hours of the continuous drug infusion.
Results are given as median (interquartile range) or numbers (percentages).
Results.
Patients receiving clonidine (n = 193) were younger (66 (57–73) vs 70 (63–77) years, p=0.003) and had a lower SAPS II (35 (27–48) vs 41 (31–54), p=0.008) compared with patients receiving dexmedetomidine (n = 141).
At the start of the drug infusion, HR (90 (75–100) vs 90 (80–105) bpm, p=0.028), MAP (70 (65–80) vs 70 (65–75) mmHg, p=0.093), and norepinephrine (0.05 (0.00–0.11) vs 0.12 (0.03–0.19) mcg/kg/min, p<0.001) were recorded in patients with clonidine and dexmedetomidine.
Bradycardia (HR < 60 bpm) developed in 7.8% with clonidine and 5.7% with dexmedetomidine (p=0.51).
Between baseline and 12 hours, norepinephrine remained stable in the clonidine group (0.00 (−0.04–0.02) mcg/kg/min) and decreased in the dexmedetomidine group (−0.03 (−0.10–0.02) mcg/kg/min, p=0.007).
Conclusions.
Dexmedetomidine and the low-cost drug clonidine can both be used safely in selected patients after cardiac surgery.
American Psychological Association (APA)
Grest, Angelina& Kurmann, Judith& Müller, Markus& Jeger, Victor& Krüger, Bernard& Spahn, Donat R.…[et al.]. 2020. Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery. Critical Care Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138524
Modern Language Association (MLA)
Grest, Angelina…[et al.]. Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery. Critical Care Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138524
American Medical Association (AMA)
Grest, Angelina& Kurmann, Judith& Müller, Markus& Jeger, Victor& Krüger, Bernard& Spahn, Donat R.…[et al.]. Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery. Critical Care Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138524