![](/images/graphics-bg.png)
The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin
المؤلفون المشاركون
Ishihara, Kazuhiko
Shimada, Kyosuke
Matsuda, Sachiko
Jinno, Hiromitsu
Kameyama, Noriaki
Konno, Tomohiro
Arai, Tsunenori
Kitagawa, Yuko
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated.
Materials and Methods.
Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB).
The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm.
Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute.
Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups.
Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated.
Results.
The concentration of verteporfin in SLN was significantly higher than other organs.
The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%).
Conclusions.
These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shimada, Kyosuke& Matsuda, Sachiko& Jinno, Hiromitsu& Kameyama, Noriaki& Konno, Tomohiro& Arai, Tsunenori…[et al.]. 2017. The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138567
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shimada, Kyosuke…[et al.]. The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138567
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shimada, Kyosuke& Matsuda, Sachiko& Jinno, Hiromitsu& Kameyama, Noriaki& Konno, Tomohiro& Arai, Tsunenori…[et al.]. The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138567
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138567
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)