The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin
Joint Authors
Ishihara, Kazuhiko
Shimada, Kyosuke
Matsuda, Sachiko
Jinno, Hiromitsu
Kameyama, Noriaki
Konno, Tomohiro
Arai, Tsunenori
Kitagawa, Yuko
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated.
Materials and Methods.
Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB).
The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm.
Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute.
Fifty-three mice were randomly assigned to the combination of PMB-verteporfin injection and light exposure, light exposure alone, PMB-verteporfin injection alone, and no treatment groups.
Ten days after PDT, brachial lymph nodes, which were considered as SLNs, were harvested and evaluated.
Results.
The concentration of verteporfin in SLN was significantly higher than other organs.
The combination of PMB-verteporfin injection and light exposure group significantly reduced the SLN metastasis (13%) comparing with no treatment group (52%), light exposure alone group (57%), and PMB-verteporfin injection alone group (46%).
Conclusions.
These data suggested that PDT using PMB as a nanotransporter of verteporfin could be a minimally invasive treatment of SLN metastasis in breast cancer and represent a potential alternative procedure to SLNB.
American Psychological Association (APA)
Shimada, Kyosuke& Matsuda, Sachiko& Jinno, Hiromitsu& Kameyama, Noriaki& Konno, Tomohiro& Arai, Tsunenori…[et al.]. 2017. The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138567
Modern Language Association (MLA)
Shimada, Kyosuke…[et al.]. The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138567
American Medical Association (AMA)
Shimada, Kyosuke& Matsuda, Sachiko& Jinno, Hiromitsu& Kameyama, Noriaki& Konno, Tomohiro& Arai, Tsunenori…[et al.]. The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138567