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Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors
المؤلفون المشاركون
Wittawatmongkol, Orasri
Santiprabhob, Jeerunda
Tanchaweng, Surapong
Maturapat, Sirinoot
Maleesatharn, Alan
Lermankul, Watcharee
Sricharoenchai, Sirintip
Lapphra, Keswadee
Phongsamart, Wanatpreeya
Chokephaibulkit, Kulkanya
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-15
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents.
This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months.
Eighty adolescents were enrolled [median (IQR) age 16.7 (14.6–18.0) years, 42 males].
Metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM) were found in 8 (10%), 17 (22.1%), and 3 (3.8%) adolescents, respectively.
Dyslipidemia was found in 56 (70%) adolescents, with hypertriglyceridemia being the most common type.
In multivariate analysis, presence of lipohypertrophy (OR: 25.7, 95% CI: 3.2–202.8; p=0.002) and longer duration of PI use (OR: 1.04, 95% CI: 1.00–1.08; p=0.023) were associated with metabolic syndrome.
Obesity (OR: 7.71, 95% CI: 1.36–43.7; p=0.021), presence of lipohypertrophy (OR: 62.9, 95% CI: 4.97–795.6; p=0.001), and exposure to stavudine for ≥6 months (OR: 8.18, 95% CI: 1.37–48.7; p=0.021) were associated with prediabetes/T2DM, while exposure to tenofovir for ≥6 months reduced the risk (OR: 0.17, 95% CI: 0.04–0.78; p=0.022).
Metabolic disorders were commonly found in adolescents receiving PI.
Careful monitoring and early intervention to modify cardiovascular risk should be systematically implemented in this population particularly those with exposure to stavudine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santiprabhob, Jeerunda& Tanchaweng, Surapong& Maturapat, Sirinoot& Maleesatharn, Alan& Lermankul, Watcharee& Sricharoenchai, Sirintip…[et al.]. 2017. Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1138621
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santiprabhob, Jeerunda…[et al.]. Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1138621
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santiprabhob, Jeerunda& Tanchaweng, Surapong& Maturapat, Sirinoot& Maleesatharn, Alan& Lermankul, Watcharee& Sricharoenchai, Sirintip…[et al.]. Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1138621
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138621
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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