![](/images/graphics-bg.png)
Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities
المؤلفون المشاركون
Esposito, Pasquale
Libetta, Carmelo
Rampino, Teresa
La Porta, Edoardo
Calatroni, Marta
Grignano, Maria Antonietta
Milanesi, Samantha
Verzola, Daniela
Gregorini, Marilena
Battaglia, Yuri
Garibotto, G.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels.
Methods.
We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafiltration (HDF).
Clinical data, laboratory parameters, and myostatin and HGF serum levels were collected and compared.
Results.
Ten patients and six controls (C) were evaluated.
In any experimental condition myostatin and HGF levels were higher in HD than in C.
At enrollment and after BHD there were not significant correlations, whereas at the end of the HDF treatment period myostatin and HGF were inversely correlated (r -0.65, p<0.05), myostatin serum levels inversely correlated with transferrin (r -0.73, p<0.05), and HGF levels that resulted positively correlated with BMI (r 0.67, p<0.05).
Moving from BHD to HDF, clinical and laboratory parameters were unchanged, as well as serum HGF, whereas myostatin levels significantly decreased (6.3 ± 4.1 versus 4.3 ± 3.1 ng/ml, p<0.05).
Conclusions.
Modulation of myostatin levels and myostatin/HGF balance by the use of different HD modalities might represent a novel approach to the prevention and treatment of HD-related muscle wasting syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Esposito, Pasquale& La Porta, Edoardo& Calatroni, Marta& Grignano, Maria Antonietta& Milanesi, Samantha& Verzola, Daniela…[et al.]. 2017. Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Esposito, Pasquale…[et al.]. Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1138688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Esposito, Pasquale& La Porta, Edoardo& Calatroni, Marta& Grignano, Maria Antonietta& Milanesi, Samantha& Verzola, Daniela…[et al.]. Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)