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Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities
Joint Authors
Esposito, Pasquale
Libetta, Carmelo
Rampino, Teresa
La Porta, Edoardo
Calatroni, Marta
Grignano, Maria Antonietta
Milanesi, Samantha
Verzola, Daniela
Gregorini, Marilena
Battaglia, Yuri
Garibotto, G.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels.
Methods.
We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafiltration (HDF).
Clinical data, laboratory parameters, and myostatin and HGF serum levels were collected and compared.
Results.
Ten patients and six controls (C) were evaluated.
In any experimental condition myostatin and HGF levels were higher in HD than in C.
At enrollment and after BHD there were not significant correlations, whereas at the end of the HDF treatment period myostatin and HGF were inversely correlated (r -0.65, p<0.05), myostatin serum levels inversely correlated with transferrin (r -0.73, p<0.05), and HGF levels that resulted positively correlated with BMI (r 0.67, p<0.05).
Moving from BHD to HDF, clinical and laboratory parameters were unchanged, as well as serum HGF, whereas myostatin levels significantly decreased (6.3 ± 4.1 versus 4.3 ± 3.1 ng/ml, p<0.05).
Conclusions.
Modulation of myostatin levels and myostatin/HGF balance by the use of different HD modalities might represent a novel approach to the prevention and treatment of HD-related muscle wasting syndrome.
American Psychological Association (APA)
Esposito, Pasquale& La Porta, Edoardo& Calatroni, Marta& Grignano, Maria Antonietta& Milanesi, Samantha& Verzola, Daniela…[et al.]. 2017. Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138688
Modern Language Association (MLA)
Esposito, Pasquale…[et al.]. Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1138688
American Medical Association (AMA)
Esposito, Pasquale& La Porta, Edoardo& Calatroni, Marta& Grignano, Maria Antonietta& Milanesi, Samantha& Verzola, Daniela…[et al.]. Modulation of MyostatinHepatocyte Growth Factor Balance by Different Hemodialysis Modalities. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138688