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Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy
المؤلفون المشاركون
Wang, Shuqiang
Hong, Quan
Geng, Xiaodong
Wu, Di
Wang, Xu
Lu, Yang
Zheng, Wei
Song, Chengcheng
Liu, Chunling
Fan, Meng
Xi, Yue
Guo, Mandi
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Membranous nephropathy (MN) is an autoimmune inflammatory disease in which proteins related with plenty of biological processes play an important role.
However, the role of these proteins in the pathogenesis of MN is still unclear.
This study aimed to screen differential proteins in kidney tissue samples from MN patients by using protein arrays and determine the pathways involved in the pathogenesis of MN.
This study first tested a quantitative protein array (QAH-INF-3) and two semiquantitative protein arrays (L-493 and L-507) with normal renal tissue and identified L-493 as the most appropriate assay to compare protein levels between MN tissues and normal control tissues.
The L-493 array identified 66 differentially expressed proteins (DEPs) that may be associated with MN.
The gene oncology (GO) and protein-protein interaction (PPI) analyses revealed several processes potentially involved in MN, including extracellular matrix disassembly and organization, cell adhesion, cell-cell signaling, cellular protein metabolic process, and immune response (P<0.05).
We suggest that these different pathways work together via protein signaling and result in the pathogenesis and progression of MN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shuqiang& Lu, Yang& Hong, Quan& Geng, Xiaodong& Wang, Xu& Zheng, Wei…[et al.]. 2017. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138740
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shuqiang…[et al.]. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138740
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shuqiang& Lu, Yang& Hong, Quan& Geng, Xiaodong& Wang, Xu& Zheng, Wei…[et al.]. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138740
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138740
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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