Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy
Joint Authors
Wang, Shuqiang
Hong, Quan
Geng, Xiaodong
Wu, Di
Wang, Xu
Lu, Yang
Zheng, Wei
Song, Chengcheng
Liu, Chunling
Fan, Meng
Xi, Yue
Guo, Mandi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Membranous nephropathy (MN) is an autoimmune inflammatory disease in which proteins related with plenty of biological processes play an important role.
However, the role of these proteins in the pathogenesis of MN is still unclear.
This study aimed to screen differential proteins in kidney tissue samples from MN patients by using protein arrays and determine the pathways involved in the pathogenesis of MN.
This study first tested a quantitative protein array (QAH-INF-3) and two semiquantitative protein arrays (L-493 and L-507) with normal renal tissue and identified L-493 as the most appropriate assay to compare protein levels between MN tissues and normal control tissues.
The L-493 array identified 66 differentially expressed proteins (DEPs) that may be associated with MN.
The gene oncology (GO) and protein-protein interaction (PPI) analyses revealed several processes potentially involved in MN, including extracellular matrix disassembly and organization, cell adhesion, cell-cell signaling, cellular protein metabolic process, and immune response (P<0.05).
We suggest that these different pathways work together via protein signaling and result in the pathogenesis and progression of MN.
American Psychological Association (APA)
Wang, Shuqiang& Lu, Yang& Hong, Quan& Geng, Xiaodong& Wang, Xu& Zheng, Wei…[et al.]. 2017. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138740
Modern Language Association (MLA)
Wang, Shuqiang…[et al.]. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138740
American Medical Association (AMA)
Wang, Shuqiang& Lu, Yang& Hong, Quan& Geng, Xiaodong& Wang, Xu& Zheng, Wei…[et al.]. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138740