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PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration
المؤلفون المشاركون
Wang, Shengguang
Zhang, Hua
Zhu, Jianquan
Li, Chenguang
Zhu, Jinfang
Shi, Bowen
Zhang, Bin
Wang, Changli
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
PinX1 has been identified as a suppressor of telomerase enzymatic activity.
However, the tumour-suppressive roles of PinX1 in different types of human cancers are unclear.
PinX1 expression status and its correlation with clinicopathological features in non-small-cell lung cancer (NSCLC) have not been investigated.
Accordingly, in this study, we aimed to evaluate the roles of PinX1 in NSCLC.
PinX1 expression status was examined by immunohistochemistry using tissue microarray from a total of 158 patients.
Correlations among PinX1 expression, clinicopathological variables, and patient survival were analysed.
Furthermore, we overexpressed PinX1 in NSCLC cells and tested telomerase activity using real-time quantitative telomeric repeat amplification protocol (qTRAP) assays.
Proliferation and migration of NSCLC cells were examined using the MTS method, wound healing assays, and transwell assays, respectively.
Our results showed that negative PinX1 expression was associated with a poor prognosis in NSCLC.
Sex, smoking status, lymph gland status, subcarinal lymph node status, pathological stage, and PinX1 expression were related to survival.
PinX1 was not an independent prognostic factor in NSCLC.
PinX1 overexpression inhibited proliferation and migration in NSCLC cells by suppressing telomerase activity.
Our findings suggested that PinX1 could be a potential tumour suppressor in NSCLC and that loss of PinX1 promoted NSCLC progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shengguang& Zhang, Hua& Zhu, Jianquan& Li, Chenguang& Zhu, Jinfang& Shi, Bowen…[et al.]. 2017. PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138821
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shengguang…[et al.]. PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138821
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shengguang& Zhang, Hua& Zhu, Jianquan& Li, Chenguang& Zhu, Jinfang& Shi, Bowen…[et al.]. PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138821
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138821
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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