PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration
Joint Authors
Wang, Shengguang
Zhang, Hua
Zhu, Jianquan
Li, Chenguang
Zhu, Jinfang
Shi, Bowen
Zhang, Bin
Wang, Changli
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
PinX1 has been identified as a suppressor of telomerase enzymatic activity.
However, the tumour-suppressive roles of PinX1 in different types of human cancers are unclear.
PinX1 expression status and its correlation with clinicopathological features in non-small-cell lung cancer (NSCLC) have not been investigated.
Accordingly, in this study, we aimed to evaluate the roles of PinX1 in NSCLC.
PinX1 expression status was examined by immunohistochemistry using tissue microarray from a total of 158 patients.
Correlations among PinX1 expression, clinicopathological variables, and patient survival were analysed.
Furthermore, we overexpressed PinX1 in NSCLC cells and tested telomerase activity using real-time quantitative telomeric repeat amplification protocol (qTRAP) assays.
Proliferation and migration of NSCLC cells were examined using the MTS method, wound healing assays, and transwell assays, respectively.
Our results showed that negative PinX1 expression was associated with a poor prognosis in NSCLC.
Sex, smoking status, lymph gland status, subcarinal lymph node status, pathological stage, and PinX1 expression were related to survival.
PinX1 was not an independent prognostic factor in NSCLC.
PinX1 overexpression inhibited proliferation and migration in NSCLC cells by suppressing telomerase activity.
Our findings suggested that PinX1 could be a potential tumour suppressor in NSCLC and that loss of PinX1 promoted NSCLC progression.
American Psychological Association (APA)
Wang, Shengguang& Zhang, Hua& Zhu, Jianquan& Li, Chenguang& Zhu, Jinfang& Shi, Bowen…[et al.]. 2017. PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138821
Modern Language Association (MLA)
Wang, Shengguang…[et al.]. PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138821
American Medical Association (AMA)
Wang, Shengguang& Zhang, Hua& Zhu, Jianquan& Li, Chenguang& Zhu, Jinfang& Shi, Bowen…[et al.]. PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138821