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Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease
المؤلفون المشاركون
Yin, Linlin
Min, Li
Jiang, Hailun
Guo, Qingdong
Guo, Shuilong
Wang, Lin-lin
Zhang, Jun-xia
Shao, Shuai
Xing, Jian-guo
Liu, Jiang-hong
Liu, Rui
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are small noncoding RNAs, which regulate numerous cell functions by targeting mRNA for cleavage or translational repression, and have been found to play an important role in Alzheimer’s disease (AD).
Our study aimed to identify differentially expressed miRNAs in AD brain as a reference of potential therapeutic miRNAs or biomarkers for this disease.
We used amyloid precursor protein (APP) and presenilin 1 (PS1) double transgenic mice and age-matched wild-type (WT) littermates to determine the expression of miRNAs in the brain.
MiRNAs were profiled by microarray, and differentially expressed miRNAs underwent target prediction and enrichment analysis.
Microarray analysis revealed 56 differentially expressed miRNAs in AD mouse brain, which involved 39 miRNAs that were significantly upregulated and 19 that were downregulated at different ages.
Among those miRNAs, a total of 11 miRNAs, including miR-342-3p, miR-342-5p, miR-376c-3p, and miR-301b-3p, were not only conserved in human but also predicted to have targets and signaling pathways closely related to the pathology of AD.
In conclusion, in this study, differentially expressed miRNAs were identified in AD brain and proposed as biomarkers, which may have the potential to indicate AD progression.
Despite being preliminary, these results may aid in investigating pathological hallmarks and identify effective therapeutic targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lin-lin& Min, Li& Guo, Qingdong& Zhang, Jun-xia& Jiang, Hailun& Shao, Shuai…[et al.]. 2017. Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lin-lin…[et al.]. Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1138863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lin-lin& Min, Li& Guo, Qingdong& Zhang, Jun-xia& Jiang, Hailun& Shao, Shuai…[et al.]. Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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