![](/images/graphics-bg.png)
Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease
Joint Authors
Yin, Linlin
Min, Li
Jiang, Hailun
Guo, Qingdong
Guo, Shuilong
Wang, Lin-lin
Zhang, Jun-xia
Shao, Shuai
Xing, Jian-guo
Liu, Jiang-hong
Liu, Rui
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are small noncoding RNAs, which regulate numerous cell functions by targeting mRNA for cleavage or translational repression, and have been found to play an important role in Alzheimer’s disease (AD).
Our study aimed to identify differentially expressed miRNAs in AD brain as a reference of potential therapeutic miRNAs or biomarkers for this disease.
We used amyloid precursor protein (APP) and presenilin 1 (PS1) double transgenic mice and age-matched wild-type (WT) littermates to determine the expression of miRNAs in the brain.
MiRNAs were profiled by microarray, and differentially expressed miRNAs underwent target prediction and enrichment analysis.
Microarray analysis revealed 56 differentially expressed miRNAs in AD mouse brain, which involved 39 miRNAs that were significantly upregulated and 19 that were downregulated at different ages.
Among those miRNAs, a total of 11 miRNAs, including miR-342-3p, miR-342-5p, miR-376c-3p, and miR-301b-3p, were not only conserved in human but also predicted to have targets and signaling pathways closely related to the pathology of AD.
In conclusion, in this study, differentially expressed miRNAs were identified in AD brain and proposed as biomarkers, which may have the potential to indicate AD progression.
Despite being preliminary, these results may aid in investigating pathological hallmarks and identify effective therapeutic targets.
American Psychological Association (APA)
Wang, Lin-lin& Min, Li& Guo, Qingdong& Zhang, Jun-xia& Jiang, Hailun& Shao, Shuai…[et al.]. 2017. Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138863
Modern Language Association (MLA)
Wang, Lin-lin…[et al.]. Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1138863
American Medical Association (AMA)
Wang, Lin-lin& Min, Li& Guo, Qingdong& Zhang, Jun-xia& Jiang, Hailun& Shao, Shuai…[et al.]. Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1138863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138863