Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise
المؤلفون المشاركون
Chi, Aiping
Shao, Changzhuan
Ren, Yiming
Wang, Zinan
Kang, Chenzhe
Jiang, Hongke
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
The aim of the present study was to elucidate the metabolic mechanisms associated with chronic fatigue syndrome (CFS) via an analysis of urine metabolites prior to and following exercise in a rat model.
Methods.
A rat model of CFS was established using restraint-stress, forced exercise, and crowded and noisy environments over a period of 4 weeks.
Behavioral experiments were conducted in order to evaluate the model.
Urine metabolites were analyzed via gas chromatography-mass spectrometry (GC-MS) in combination with multivariate statistical analysis before and after exercise.
Results.
A total of 20 metabolites were detected in CFS rats before and after exercise.
Three metabolic pathways (TCA cycle; alanine, aspartate, and glutamate metabolism; steroid hormone biosynthesis) were significantly impacted before and after exercise, while sphingolipid metabolism alone exhibited significant alterations after exercise only.
Conclusion.
In addition to metabolic disturbances involving some energy substances, alterations in steroid hormone biosynthesis and sphingolipid metabolism were detected in CFS rats.
Sphingosine and 21-hydroxypregnenolone may be key biomarkers of CFS, potentially offering evidence in support of immune dysfunction and hypothalamic-pituitary-adrenal (HPA) axis hypoactivity in patients with CFS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shao, Changzhuan& Ren, Yiming& Wang, Zinan& Kang, Chenzhe& Jiang, Hongke& Chi, Aiping. 2017. Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138947
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shao, Changzhuan…[et al.]. Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138947
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shao, Changzhuan& Ren, Yiming& Wang, Zinan& Kang, Chenzhe& Jiang, Hongke& Chi, Aiping. Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138947
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138947
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر