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Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise
Joint Authors
Chi, Aiping
Shao, Changzhuan
Ren, Yiming
Wang, Zinan
Kang, Chenzhe
Jiang, Hongke
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
The aim of the present study was to elucidate the metabolic mechanisms associated with chronic fatigue syndrome (CFS) via an analysis of urine metabolites prior to and following exercise in a rat model.
Methods.
A rat model of CFS was established using restraint-stress, forced exercise, and crowded and noisy environments over a period of 4 weeks.
Behavioral experiments were conducted in order to evaluate the model.
Urine metabolites were analyzed via gas chromatography-mass spectrometry (GC-MS) in combination with multivariate statistical analysis before and after exercise.
Results.
A total of 20 metabolites were detected in CFS rats before and after exercise.
Three metabolic pathways (TCA cycle; alanine, aspartate, and glutamate metabolism; steroid hormone biosynthesis) were significantly impacted before and after exercise, while sphingolipid metabolism alone exhibited significant alterations after exercise only.
Conclusion.
In addition to metabolic disturbances involving some energy substances, alterations in steroid hormone biosynthesis and sphingolipid metabolism were detected in CFS rats.
Sphingosine and 21-hydroxypregnenolone may be key biomarkers of CFS, potentially offering evidence in support of immune dysfunction and hypothalamic-pituitary-adrenal (HPA) axis hypoactivity in patients with CFS.
American Psychological Association (APA)
Shao, Changzhuan& Ren, Yiming& Wang, Zinan& Kang, Chenzhe& Jiang, Hongke& Chi, Aiping. 2017. Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138947
Modern Language Association (MLA)
Shao, Changzhuan…[et al.]. Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1138947
American Medical Association (AMA)
Shao, Changzhuan& Ren, Yiming& Wang, Zinan& Kang, Chenzhe& Jiang, Hongke& Chi, Aiping. Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1138947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138947