A Drug-Induced Acute Pancreatitis Retrospective Study
المؤلفون المشاركون
Gagnon, Ann-Lorie
Lavoie, Alexandre
Frigon, Marie-Pier
Michaud-Herbst, Alban
Tremblay, Karine
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Aims.
Drugs are considered a relatively rare and understudied cause of acute pancreatitis (AP).
The lack of convincing and conclusive data on drug-induced AP (DIAP) complicates the diagnosis as well as the identification of the causative drug.
The aim of this study is to document causes of DIAP cases that occurred in the Saguenay-Lac-Saint-Jean (SLSJ) population.
Methods.
We have conducted a retrospective and descriptive population-based study of DIAP cases that occurred between 2006 and 2014 in the six hospitals serving the entire SLSJ population.
Cases were selected from the Quebec Ministry of Health hospitalizations registry (MED-ECHO) administrative public database.
A medical chart review was performed in an attempt to characterize DIAP hospitalizations and to identify the imputable drugs.
Results.
During the studied period, 75 cases (30.7% male, 69.3% female) were included totaling 90 hospitalizations for DIAP.
Among them, 50 causative drugs were identified and were distributed in 17 different drug classes.
Recurrent DIAPs were documented in 13 cases, and among them, 6 cases have experimented a positive rechallenge.
Six drugs (5-fluorouracil, atorvastatin, bortezomib, nilotinib, rosuvastatin, and triamcinolone) were associated with the highest degree of evidence.
The most common causative drugs of DIAP hospitalization were azathioprine (n = 7), followed by atorvastatin (n = 6), hydrochlorothiazide (n = 5), rosuvastatin (n = 4), and codeine (n = 4).
Conclusions.
This study has added new evidences about potentially pancreatitis-associated drugs in literature.
This is the first study to report definite 5-fluorouracil- and triamcinolone-induced AP.
An updated version of the evidence-based literature review is needed to support the clinicians in the identification of the causative drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gagnon, Ann-Lorie& Lavoie, Alexandre& Frigon, Marie-Pier& Michaud-Herbst, Alban& Tremblay, Karine. 2020. A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gagnon, Ann-Lorie…[et al.]. A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gagnon, Ann-Lorie& Lavoie, Alexandre& Frigon, Marie-Pier& Michaud-Herbst, Alban& Tremblay, Karine. A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر