A Drug-Induced Acute Pancreatitis Retrospective Study
Joint Authors
Gagnon, Ann-Lorie
Lavoie, Alexandre
Frigon, Marie-Pier
Michaud-Herbst, Alban
Tremblay, Karine
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aims.
Drugs are considered a relatively rare and understudied cause of acute pancreatitis (AP).
The lack of convincing and conclusive data on drug-induced AP (DIAP) complicates the diagnosis as well as the identification of the causative drug.
The aim of this study is to document causes of DIAP cases that occurred in the Saguenay-Lac-Saint-Jean (SLSJ) population.
Methods.
We have conducted a retrospective and descriptive population-based study of DIAP cases that occurred between 2006 and 2014 in the six hospitals serving the entire SLSJ population.
Cases were selected from the Quebec Ministry of Health hospitalizations registry (MED-ECHO) administrative public database.
A medical chart review was performed in an attempt to characterize DIAP hospitalizations and to identify the imputable drugs.
Results.
During the studied period, 75 cases (30.7% male, 69.3% female) were included totaling 90 hospitalizations for DIAP.
Among them, 50 causative drugs were identified and were distributed in 17 different drug classes.
Recurrent DIAPs were documented in 13 cases, and among them, 6 cases have experimented a positive rechallenge.
Six drugs (5-fluorouracil, atorvastatin, bortezomib, nilotinib, rosuvastatin, and triamcinolone) were associated with the highest degree of evidence.
The most common causative drugs of DIAP hospitalization were azathioprine (n = 7), followed by atorvastatin (n = 6), hydrochlorothiazide (n = 5), rosuvastatin (n = 4), and codeine (n = 4).
Conclusions.
This study has added new evidences about potentially pancreatitis-associated drugs in literature.
This is the first study to report definite 5-fluorouracil- and triamcinolone-induced AP.
An updated version of the evidence-based literature review is needed to support the clinicians in the identification of the causative drugs.
American Psychological Association (APA)
Gagnon, Ann-Lorie& Lavoie, Alexandre& Frigon, Marie-Pier& Michaud-Herbst, Alban& Tremblay, Karine. 2020. A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138995
Modern Language Association (MLA)
Gagnon, Ann-Lorie…[et al.]. A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138995
American Medical Association (AMA)
Gagnon, Ann-Lorie& Lavoie, Alexandre& Frigon, Marie-Pier& Michaud-Herbst, Alban& Tremblay, Karine. A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138995