The Roles of Thrombospondins in Hemorrhagic Stroke

الملخص EN

Hemorrhagic stroke is a devastating cerebrovascular disease with significant morbidity and mortality worldwide.

Thrombospondins (TSPs), as matricellular proteins, belong to the TSP family which is comprised of five members.

All TSPs modulate a variety of cellular functions by binding to various receptors.

Recently, TSPs gained attention in the area of hemorrhagic stroke, especially TSP-1.

TSP-1 participates in angiogenesis, the inflammatory response, apoptosis, and fibrosis after hemorrhagic stroke through binding to various molecules including but not limited to CD36, CD47, and TGF-β.

In this review, we will discuss the roles of TSPs in hemorrhagic stroke and focus primarily on TSP-1.