Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes
المؤلفون المشاركون
Liu, Yang
Zheng, Ke
Liu, Yecheng
Zhu, Huadong
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
With immunosuppressants being widely used, Pneumocystis jirovecii pneumonia (PCP) has been increasing and could be life-threatening among HIV-negative patients.
This study aimed at identifying prognostic factors of PCP in patients with nephrotic syndrome.
Methods.
We retrospectively investigated patients with nephrotic syndrome who were diagnosed with PCP.
The diagnosis of PCP was based on clinical manifestations, radiological findings, and microbiological confirmatory tests.
Predictors of outcome were determined with multivariate logistic regression analysis.
Results.
A total of 57 patients were included in this study.
The PCP mortality was 33.3%, which increased to 48.6% if ICU admission was required and to 60% when mechanical ventilation was needed.
The T lymphocyte count and CD4/CD8 ratio independently predicted the outcome of PCP, so did the CD4+ T lymphocyte count (OR, 0.981; 95% CI, 0.967–0.996; p=0.001).
The cut-off value of 71 cells/μl for the CD4+ T lymphocyte count was determined to identify patients with poor prognosis.
No association was found between PCP mortality and the type of immunosuppressant used.
Conclusions.
PCP is a fatal complication among nephrotic syndrome patients receiving immunosuppressive therapy.
The CD4+ T lymphocyte count is suggested as an independent predictor of prognosis, which can be used clinically to identify patients with high risk of unfavorable outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yang& Zheng, Ke& Liu, Yecheng& Zhu, Huadong. 2020. Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139128
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yang…[et al.]. Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1139128
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yang& Zheng, Ke& Liu, Yecheng& Zhu, Huadong. Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139128
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139128
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر