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Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes
Joint Authors
Liu, Yang
Zheng, Ke
Liu, Yecheng
Zhu, Huadong
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
With immunosuppressants being widely used, Pneumocystis jirovecii pneumonia (PCP) has been increasing and could be life-threatening among HIV-negative patients.
This study aimed at identifying prognostic factors of PCP in patients with nephrotic syndrome.
Methods.
We retrospectively investigated patients with nephrotic syndrome who were diagnosed with PCP.
The diagnosis of PCP was based on clinical manifestations, radiological findings, and microbiological confirmatory tests.
Predictors of outcome were determined with multivariate logistic regression analysis.
Results.
A total of 57 patients were included in this study.
The PCP mortality was 33.3%, which increased to 48.6% if ICU admission was required and to 60% when mechanical ventilation was needed.
The T lymphocyte count and CD4/CD8 ratio independently predicted the outcome of PCP, so did the CD4+ T lymphocyte count (OR, 0.981; 95% CI, 0.967–0.996; p=0.001).
The cut-off value of 71 cells/μl for the CD4+ T lymphocyte count was determined to identify patients with poor prognosis.
No association was found between PCP mortality and the type of immunosuppressant used.
Conclusions.
PCP is a fatal complication among nephrotic syndrome patients receiving immunosuppressive therapy.
The CD4+ T lymphocyte count is suggested as an independent predictor of prognosis, which can be used clinically to identify patients with high risk of unfavorable outcomes.
American Psychological Association (APA)
Liu, Yang& Zheng, Ke& Liu, Yecheng& Zhu, Huadong. 2020. Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139128
Modern Language Association (MLA)
Liu, Yang…[et al.]. Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1139128
American Medical Association (AMA)
Liu, Yang& Zheng, Ke& Liu, Yecheng& Zhu, Huadong. Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1139128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139128