The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients
المؤلفون المشاركون
Xie, Liyi
Jin, Li
Feng, Jie
Lv, Jing
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To research the distribution and quantitative changes of UT-A1, UT-B1, and AQP5 in uremic skin tissue.
Methods.
34 cases of uremic patients (UP) and 11 controls were recruited.
Immunohistochemistry, immunofluorescence, RT-PCR, and Western Blot were used to identify the proteins in sweat glands.
Results.
AQP5, UT-A1, and UT-B1 were expressed and localized in human skin basal lines, skin sweat glands, and sweat ducts, both in UP and controls.
Compared to controls, AQP5 mRNA abundance was significantly decreased in UP (P<0.01), and, with the decrease of eGFR, the AQP5 expression was significantly decreased (P<0.05).
By contrast, UT-A1 and UT-B1 mRNA abundance was significantly increased in the skin of UP compared with the control (P<0.01), and, with the decrease of eGFR, the AQP5 expression was significantly increased (P<0.05).
We found that the gene changes were coincident with the corresponding target proteins.
The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands.
The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased.
Conclusion.
Elimination of urea through the skin by producing sweat is a potential therapeutic strategy for renal failure patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Liyi& Jin, Li& Feng, Jie& Lv, Jing. 2017. The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Liyi…[et al.]. The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Liyi& Jin, Li& Feng, Jie& Lv, Jing. The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر