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The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients
Joint Authors
Xie, Liyi
Jin, Li
Feng, Jie
Lv, Jing
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To research the distribution and quantitative changes of UT-A1, UT-B1, and AQP5 in uremic skin tissue.
Methods.
34 cases of uremic patients (UP) and 11 controls were recruited.
Immunohistochemistry, immunofluorescence, RT-PCR, and Western Blot were used to identify the proteins in sweat glands.
Results.
AQP5, UT-A1, and UT-B1 were expressed and localized in human skin basal lines, skin sweat glands, and sweat ducts, both in UP and controls.
Compared to controls, AQP5 mRNA abundance was significantly decreased in UP (P<0.01), and, with the decrease of eGFR, the AQP5 expression was significantly decreased (P<0.05).
By contrast, UT-A1 and UT-B1 mRNA abundance was significantly increased in the skin of UP compared with the control (P<0.01), and, with the decrease of eGFR, the AQP5 expression was significantly increased (P<0.05).
We found that the gene changes were coincident with the corresponding target proteins.
The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands.
The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased.
Conclusion.
Elimination of urea through the skin by producing sweat is a potential therapeutic strategy for renal failure patients.
American Psychological Association (APA)
Xie, Liyi& Jin, Li& Feng, Jie& Lv, Jing. 2017. The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139204
Modern Language Association (MLA)
Xie, Liyi…[et al.]. The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139204
American Medical Association (AMA)
Xie, Liyi& Jin, Li& Feng, Jie& Lv, Jing. The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139204