99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits
المؤلفون المشاركون
Persico, Marco Giovanni
Marenco, Manuela
De Matteis, Gianluca
Manfrinato, Giulia
Cavenaghi, Giorgio
Sgarella, Adele
Aprile, Carlo
Lodola, Lorenzo
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Recent developments in sentinel lymph node (SLN) and radio occult lesion localization (ROLL) highlight the need for a multimodal contrast agent, providing better presurgical PET imaging and improved intraoperative mapping thanks to fluorescence detection.
For this reason, we have studied a trimodal SLN/ROLL targeting agent (99mTc-68Ga-ICG) with commercially available kits of macroaggregated or nanocolloidal albumin (MA/NC-HSA).
68Ga PET imaging does provide better spatial resolution and makes it possible to predict signal intensity during surgery.
The presence of 99mTc assesses the efficacy of these compounds in vitro and also during the surgery procedure.
The aim of this study was to optimise the labelling and tagging of these two radiopharmaceuticals and assess their yields and stability.
Kits of MA/NC-HSA particles (Pulmocis® and NanoAlbumon®) were used for sequential radiolabelling with 99mTc and 68Ga.
Fluorescent tagging was performed using indocyanine green, a tricarbocyanine dye.
The ITLC radiochemical purity of the trilabelled MA/NC-HSA was >95%.
Fluorescent purity was measured by scanning the strips with a PhotoDynamicEye probe.
Finally, in vitro stability tests, performed with DTPA and human serum solutions, assessed the efficacy of fluorescent tagging and radiolabelling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Persico, Marco Giovanni& Marenco, Manuela& De Matteis, Gianluca& Manfrinato, Giulia& Cavenaghi, Giorgio& Sgarella, Adele…[et al.]. 2020. 99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits. Contrast Media & Molecular Imaging،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139242
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Persico, Marco Giovanni…[et al.]. 99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits. Contrast Media & Molecular Imaging No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1139242
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Persico, Marco Giovanni& Marenco, Manuela& De Matteis, Gianluca& Manfrinato, Giulia& Cavenaghi, Giorgio& Sgarella, Adele…[et al.]. 99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits. Contrast Media & Molecular Imaging. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1139242
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139242
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر