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Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents
المؤلفون المشاركون
Ge, Junbo
Yin, Jiasheng
Ji, Meng
Wu, Yizhe
Cai, Sishi
Chen, Jiahui
Yao, Zhifeng
Shen, Li
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Late in-stent restenosis (ISR) has raised concerns regarding the long-term efficacy of drug-eluting stents (DES).
The role of vascular endothelial growth factor (VEGF) in the pathological process of ISR is controversial.
This retrospective study aimed to investigate the relationship between serum VEGF levels and late ISR in patients with DES implantation.
A total of 158 patients who underwent angiography follow-up beyond 1 year after intervention were included.
The study population was classified into ISR and non-ISR groups.
The ISR group was further divided according to follow-up duration and Mehran classification.
VEGF levels were significantly lower in the ISR group than in the non-ISR group [96.34 (48.18, 174.14) versus 179.14 (93.59, 307.74) pg/mL, p<0.0001].
Multivariate regression revealed that VEGF level, procedure age, and low-density lipoprotein cholesterol were independent risk factors for late ISR formation.
Subgroup analysis demonstrated that VEGF levels were even lower in the very late (≥5 years) and diffuse ISR group (Mehran patterns II, III, and IV) than in the late ISR group (1–4 years) and the focal ISR group (Mehran pattern I), respectively.
Furthermore, significant difference was found between diffuse and focal ISR groups.
Serum VEGF levels were inversely associated with late ISR after DES implantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yin, Jiasheng& Shen, Li& Ji, Meng& Wu, Yizhe& Cai, Sishi& Chen, Jiahui…[et al.]. 2017. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yin, Jiasheng…[et al.]. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yin, Jiasheng& Shen, Li& Ji, Meng& Wu, Yizhe& Cai, Sishi& Chen, Jiahui…[et al.]. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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