Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents
Joint Authors
Ge, Junbo
Yin, Jiasheng
Ji, Meng
Wu, Yizhe
Cai, Sishi
Chen, Jiahui
Yao, Zhifeng
Shen, Li
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Late in-stent restenosis (ISR) has raised concerns regarding the long-term efficacy of drug-eluting stents (DES).
The role of vascular endothelial growth factor (VEGF) in the pathological process of ISR is controversial.
This retrospective study aimed to investigate the relationship between serum VEGF levels and late ISR in patients with DES implantation.
A total of 158 patients who underwent angiography follow-up beyond 1 year after intervention were included.
The study population was classified into ISR and non-ISR groups.
The ISR group was further divided according to follow-up duration and Mehran classification.
VEGF levels were significantly lower in the ISR group than in the non-ISR group [96.34 (48.18, 174.14) versus 179.14 (93.59, 307.74) pg/mL, p<0.0001].
Multivariate regression revealed that VEGF level, procedure age, and low-density lipoprotein cholesterol were independent risk factors for late ISR formation.
Subgroup analysis demonstrated that VEGF levels were even lower in the very late (≥5 years) and diffuse ISR group (Mehran patterns II, III, and IV) than in the late ISR group (1–4 years) and the focal ISR group (Mehran pattern I), respectively.
Furthermore, significant difference was found between diffuse and focal ISR groups.
Serum VEGF levels were inversely associated with late ISR after DES implantation.
American Psychological Association (APA)
Yin, Jiasheng& Shen, Li& Ji, Meng& Wu, Yizhe& Cai, Sishi& Chen, Jiahui…[et al.]. 2017. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139250
Modern Language Association (MLA)
Yin, Jiasheng…[et al.]. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1139250
American Medical Association (AMA)
Yin, Jiasheng& Shen, Li& Ji, Meng& Wu, Yizhe& Cai, Sishi& Chen, Jiahui…[et al.]. Inverse Relationship between Serum VEGF Levels and Late In-Stent Restenosis of Drug-Eluting Stents. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1139250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139250