Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients
المؤلفون المشاركون
Lin, Chengren
Jiang, Yunyao
Liu, Nan
Xue, Bingjie
Hou, Jincai
Ren, Jianxun
Liu, Jianxun
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Coronary heart disease (CHD) has become one of the leading causes of death and functional impairment in the world.
Hyperglycemia is associated with an increased risk of cardiovascular disease.
It was speculated that miRNAs in peripheral blood were a primary parameter in discriminating CHD.
The biological characteristics of coronary heart disease with hyperglycemia (HCHD) and coronary heart disease with euglycemia (ECHD) were investigated in the study.
Circulating miRNAs from 26 HCHD patients and 42 ECHD patients were identified by microarrays.
Compared with the healthy patients, 15 and 20 differentially expressed miRNAs were identified in HCHD and ECHD groups, respectively.
Gene ontology analysis was carried out by DAVID and functional annotations of the miRNA targets related to ATP binding, cellular components, protein binding, RNA binding, DNA binding, and so on.
KEGG database was used for pathway analysis.
Eleven pathways were identified in both HCHD and ECHD groups.
Furthermore, 13 and 3 pathways were only identified in HCHD or ECHD group, respectively.
And then, miRNA-gene regulatory networks were constructed to study the relationship between differentially expressed miRNAs and genes.
This suggested that hsa-let-7c-5p and hsa-miR-24-3p might have the most important function for hyperglycemia in coronary heart disease patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Yunyao& Liu, Nan& Xue, Bingjie& Hou, Jincai& Lin, Chengren& Ren, Jianxun…[et al.]. 2017. Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139393
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Yunyao…[et al.]. Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139393
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Yunyao& Liu, Nan& Xue, Bingjie& Hou, Jincai& Lin, Chengren& Ren, Jianxun…[et al.]. Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139393
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1139393
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر