Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients
Joint Authors
Lin, Chengren
Jiang, Yunyao
Liu, Nan
Xue, Bingjie
Hou, Jincai
Ren, Jianxun
Liu, Jianxun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Coronary heart disease (CHD) has become one of the leading causes of death and functional impairment in the world.
Hyperglycemia is associated with an increased risk of cardiovascular disease.
It was speculated that miRNAs in peripheral blood were a primary parameter in discriminating CHD.
The biological characteristics of coronary heart disease with hyperglycemia (HCHD) and coronary heart disease with euglycemia (ECHD) were investigated in the study.
Circulating miRNAs from 26 HCHD patients and 42 ECHD patients were identified by microarrays.
Compared with the healthy patients, 15 and 20 differentially expressed miRNAs were identified in HCHD and ECHD groups, respectively.
Gene ontology analysis was carried out by DAVID and functional annotations of the miRNA targets related to ATP binding, cellular components, protein binding, RNA binding, DNA binding, and so on.
KEGG database was used for pathway analysis.
Eleven pathways were identified in both HCHD and ECHD groups.
Furthermore, 13 and 3 pathways were only identified in HCHD or ECHD group, respectively.
And then, miRNA-gene regulatory networks were constructed to study the relationship between differentially expressed miRNAs and genes.
This suggested that hsa-let-7c-5p and hsa-miR-24-3p might have the most important function for hyperglycemia in coronary heart disease patients.
American Psychological Association (APA)
Jiang, Yunyao& Liu, Nan& Xue, Bingjie& Hou, Jincai& Lin, Chengren& Ren, Jianxun…[et al.]. 2017. Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139393
Modern Language Association (MLA)
Jiang, Yunyao…[et al.]. Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139393
American Medical Association (AMA)
Jiang, Yunyao& Liu, Nan& Xue, Bingjie& Hou, Jincai& Lin, Chengren& Ren, Jianxun…[et al.]. Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139393